84-5992-97　NCOA1 (FITC) 50ug　569812

特徴

• Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
• Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs).
• Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors.
• Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear.
• Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors.
• Required with NCOA2 to control energy balance between white and brown adipose tissues.
• Required for mediating steroid hormone response.
• Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.