84-5989-03　MYOG 100ug　569616

特徴

• Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.
• Essential for the development of functional embryonic skeletal fiber muscle differentiation.
• However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity.
• Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation.
• During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1.
• Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis.
• Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters.
• Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression.
• Binds to the E-box containing (E1) promoter region of the miR-20a gene.
• Plays also a role in preventing reversal of muscle cell differentiation.
• Contributes to the atrophy-related gene expression in adult denervated muscles.
• Induces fibroblasts to differentiate into myoblasts (By similarity).
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.