84-5988-91　MYOC (HRP) 50ug　569611

特徴

• Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration.
• Promotes substrate adhesion, spreading and formation of focal contacts.
• Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.
• Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways.
• Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.
• Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling.
• Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling.
• Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex.
• Involved in positive regulation of mitochondrial depolarization.
• Plays a role in neurite outgrowth.
• May participate in the obstruction of fluid outflow in the trabecular meshwork.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.