84-5988-85　MYOC 50ug　569608

特徴

• Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration.
• Promotes substrate adhesion, spreading and formation of focal contacts.
• Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.
• Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways.
• Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling.
• Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling.
• Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling.
• Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex.
• Involved in positive regulation of mitochondrial depolarization.
• Plays a role in neurite outgrowth.
• May participate in the obstruction of fluid outflow in the trabecular meshwork.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:5000Immunohistochemistry: 1:200-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.