Myosins are actin-based motor molecules with ATPase activity.
Unconventional myosins serve in intracellular movements.
Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments.
In the retina, plays an important role in the renewal of the outer photoreceptor disks.
Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors.
In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles.
Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity).
Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells.
Required for normal hearing.
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human MYO7A.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa838-968 from human unconventional myosin-VIIa protein.
