84-5958-35　MAP3K5 50ug　568098

特徴

• Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
• Plays an important role in the cascades of cellular responses evoked by changes in the environment.
• Mediates signaling for determination of cell fate such as differentiation and survival.
• Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.
• MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens.
• Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS).
• Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.
• These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs).
• Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
• Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunoflourescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.