Involved in embryonic lens fiber cell development.
Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation.
Activates the expression of IL4 in T helper 2 (Th2) cells.
Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression.
Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element.
Activates transcription of the CD13 proximal promoter in endothelial cells.
Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction.
Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development.
Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter.
Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters.
Binds element G1 on the glucagon promoter.
Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity).
When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription.
Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Binds to the ARE sites of detoxifying enzyme gene promoters.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with horseradish peroxidase (HRP).
Specificity：Recognizes human MAF.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa55-180 from human transcription factor Maf protein.
