Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety.
Inactive towards proteins bearing poly-ADP-ribose.
Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.
Plays a role in estrogen signaling.
Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen.
May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation.
Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction.
Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells.
Enhances ESR1-mediated transcription activity.
Applications:Suitable for use in FLISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Fluorescein isothiocyanate (FITC).
Specificity：Recognizes human MACROD1.
Isotype：IgG
Calc Applications Abbrev：FLISA
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa83-325 from human O-acetyl-ADP-ribose deacetylase MACROD1 protein.
