Type I keratin involved in the formation and maintenance of various skinappendages, specifically in determining shape and orientation of hair.
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state.
Modulates the function of TNF-alpha in the specific context of hair cycling.
Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.
Involved in tissue repair.
May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells".
Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors.
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：bovine
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes bovine KRT17.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Bo
Immunogen：Recombinant protein corresponding to aa1-441 from bovine Keratin, type I cytoskeletal 17 protein.
