84-5927-01　KISS1 (HRP) 100ug　566546

特徴

• Metastasis suppressor protein in malignant melanomas and in some breast cancers.
• May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
• Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
• Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
• Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast.
• Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts.
• Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself.
• The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
• The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.