Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitinprotein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins.
Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization.
Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 downregulation, keeping GLI1 acetylated and inactive.
Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Involved inregulating protein levels of ANK1 isoform Mu17 probably implicating CUL3- dependent proteasomal degradation (PubMed:22573887).
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human KCTD6.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1-237 from human BTB/POZ domain-containing protein KCTD6.
