84-5921-49　KCNMB1 (HRP) 100ug　566273

特徴

• Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel.
• Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
• Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel.
• It also modifies KCNMA1 channel kinetics and alters its pharmacological properties.
• It slows down the activation and the deactivation kinetics of the channel.
• Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1.
• Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2).
• Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.