Involved in the control of cytoskeleton formation by regulating actin polymerization.
Inhibits actin fiber formation and cell migration.
Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes.
Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1.
Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2.
Inhibits neurite outgrowth.
Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing.
In the nucleus, is involved in beta-catenin-dependent activation of transcription.
Potential tumor suppressor for renal cell carcinoma.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:200-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human KANK1.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa66-255 from human KN motif and ankyrin repeat domain-containing protein 1.
