84-5918-06　JMY (FITC) 100ug　566103

特徴

• Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.
• In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300.
• Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.
• In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments.
• Activates the Arp2/3 complex to induce branched actin filament networks.
• Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments.
• Contributes to cell motility by controlling actin dynamics.
• May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments.
• The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.