84-5914-52　ISL1 (FITC) 100ug　565928

特徴

• DNA-binding transcriptional activator.
• Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes.
• Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation.
• Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina.
• Involved in the specification of motor neurons in cooperation with LHX3 and LDB1.
• Binds to insulin gene enhancer sequences.
• Essential for heart development.
• Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart.
• Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.