84-5891-59 HIPK3 100ug 564793
特徴
- Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression.
- Phosphorylates JUN and RUNX2.
- Seems to negatively regulate apoptosis by promoting FADD phosphorylation.
- Enhances androgen receptor-mediated transcription.
- May act as a transcriptional corepressor for NK homeodomain transcription factors.
- The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
- In osteoblasts, supports transcription activation.
- Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
- Other applications not tested.
- Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ug
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by Protein G affinity chromatography.
- Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Specificity：Recognizes human HIPK3.
- Isotype：IgG
- Calc Applications Abbrev：E IF IHC
- Calc Crossreactivity：Hu
- Immunogen：Recombinant protein corresponding to aa841-1130 from human homeodomain-interacting protein kinase 3 protein.
- Shelf Life：1year
- Swiss Prot Number：Q9H422
- EU Commodity Code：30021010
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