Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis.
Plays a role as a corepressor for homeodomain transcription factors.
Phosphorylates DAXX and MYB.
Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm.
Inactivates MYB transcription factor activity by phosphorylation.
Prevents MAP3K5-JNK activation in the absence of TNF.
TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis.
May be involved in anti-oxidative stress responses.
Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Promotes angiogenesis and to be involved in erythroid differentiation.
May be involved in malignant squamous cell tumor formation.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human HIPK1.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1007-1151 from human homeodomain-interacting protein kinase 1.
