Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis.
Plays a role as a corepressor for homeodomain transcription factors.
Phosphorylates DAXX and MYB.
Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm.
Inactivates MYB transcription factor activity by phosphorylation.
Prevents MAP3K5-JNK activation in the absence of TNF.
TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis.
May be involved in anti-oxidative stress responses.
Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Promotes angiogenesis and to be involved in erythroid differentiation.
May be involved in malignant squamous cell tumor formation.
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:200-1:500Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human HIPK1.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1007-1151 from human homeodomain-interacting protein kinase 1.
