84-5875-87　GPER1 (FITC) 100ug　564015

特徴

• G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways.
• Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK.
• Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems.
• Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner.
• Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation.
• Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells.
• Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation.
• Stimulates uterine epithelial cell proliferation.
• Enhances uterine contractility in response to oxytocin.
• Contributes to thymic atrophy by inducing apoptosis.
• Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules.
• Promotes neuritogenesis in developing hippocampal neurons.
• Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death.
• Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons.
• Inhibits early osteoblast proliferation at growth plate during skeletal development.
• Inhibits mature adipocyte differentiation and lipid accumulation.
• Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
• Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway.
• Involved in cancer progression regulation.
• Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway.
• Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1).
• Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.