Adapter protein that links activated FGR and NGF receptors to downstreamsignaling pathways.
Plays an important role in the activation of MAP kinasesand in the phosphorylation of PIK3R1, the regulatory subunit ofphosphatidylinositol 3-kinase, in response to ligand-mediated activation ofFGFR1.
Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human FRS2.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa116-387 from human fibroblast growth factor receptor substrate 2 protein.
