84-5854-18　FOXN1 100ug　562941

特徴

• Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus.
• Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality.
• Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1.
• Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs).
• Essential for maintenance of mTECs population in the postnatal thymus.
• Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessaryfor a fully functional thymus.
• Plays an important role in the maintenance ofhematopoiesis and particularly T lineage progenitors within the bone marrow niche with age.
• Essential for the vascularization of the thymus anlage.
• Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity).
• Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:5000Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.