84-5854-01　FOXL2 50ug　562933

特徴

• Transcriptional regulator.
• Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination.
• Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity).
• Has apoptotic activity in ovarian cells.
• Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity).
• Is a regulator of CYP19 expression (By similarity).
• Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).
• Is a transcriptional repressor of STAR.
• Activates SIRT1 transcription under cellular stress conditions.
• Activates transcription of OSR2.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.