Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability.
Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures.
Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters.
Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression.
Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation.
May be involved in regulation of telomere length.
Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element.
May function in sex development and spermatogenesis.
May play a role in ossification.
Applications:Suitable for use in FLISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Fluorescein isothiocyanate (FITC).
Specificity：Recognizes human DHX36.
Isotype：IgG
Calc Applications Abbrev：FLISA
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa68-181 from human ATP-dependent RNA helicase DHX36 protein.
