Proposed to have a global role in regulating mRNA expression includingtranscriptional regulation and mRNA stability.
Binds with high affinity to andresolves tetramolecular RNA and DNA quadruplex structures.
Unwindsintramolecular quadruplexes derived from the ZIC1 and the MYC promoters.
Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression.
Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation.
May be involved in regulation of telomere length.
Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element.
May function in sex development andspermatogenesis.
May play a role in ossification.
Applications:Suitable for use in ELISA and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human DHX36.
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa68-181 from human ATP-dependent RNA helicase DHX36 protein.
