Basic protein that bind to cell membrane and depolarizes cardiomyocytes.
This cytotoxin also shows lytic activities, but 2-fold more important than that of CTXA2.
It binds to the integrin alpha-V/beta-3 with a moderate affinity.
Inhibits protein kinase C.
It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes.
It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：Naja atra
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes Naja atra Cytotoxin 4.
Isotype：IgG
Calc Applications Abbrev：E
Immunogen：Recombinant protein corresponding to aa22-81 from Naja atra Cytotoxin 4 protein.
