84-5790-89　CYFIP1 50ug　559809

特徴

• Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression.
• In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1.
• Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity).
• Regulates formation of membrane ruffles and lamellipodia.
• Plays a role in axon outgrowth.
• Binds to F-actin but not to RNA.
• Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex.
• Actin remodeling activity is regulated by RAC1.
• Regulator of epithelial morphogenesis.
• As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
• May act as an invasion suppressor in cancers.
• Applications:Suitable for use in ELISA and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.