May indirectly participate in activation of the NF-kappa-B and MAPK pathways.
Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells.
Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest.
Involved in myelopoiesis.
Transcription factor.
Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788).
May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human CXXC5.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1-227 from human CXXC-type zinc finger protein 5 protein
