84-5788-13　CUX1 50ul　559672

特徴

• Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression.
• May act by preventing binding of positively-activing CCAAT factors to promoters.
• Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer.
• Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer.
• Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).
• Applications:Suitable for use in ELISA and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.