84-5785-01　CSNK1D (Biotin) 100ug　559517

特徴

• Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms.
• It can phosphorylate a large number of proteins.
• Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
• Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2.
• Central component of the circadian clock.
• In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.
• Controls PER1 and PER2 nuclear transport and degradation.
• YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.
• DNMT1 phosphorylation reduces its DNA-binding activity.
• Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.
• Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth.
• EIF6 phosphorylation promotes its nuclear export.
• Triggers down-regulation of dopamine receptors in the forebrain.
• Activates DCK in vitro by phosphorylation.
• TOP2A phosphorylation favors DNA cleavable complex formation.
• May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast.
• Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
• Probably involved in lymphocyte physiology.
• Regulates fast synaptic transmission mediated by glutamate.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.