Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms.
It can phosphorylate a large number of proteins.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.
Controls PER1 and PER2 nuclear transport and degradation.
YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.
DNMT1 phosphorylation reduces its DNA-binding activity.
Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.
Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth.
EIF6 phosphorylation promotes its nuclear export.
Triggers down-regulation of dopamine receptors in the forebrain.
Activates DCK in vitro by phosphorylation.
TOP2A phosphorylation favors DNA cleavable complex formation.
May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast.
Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.
Probably involved in lymphocyte physiology.
Regulates fast synaptic transmission mediated by glutamate.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000-1:5000Immunohistochemistry: 1:1000-1:2000Immunofluorescence: 1:200-1:500Immunoprecipitation: 1:200-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human CSNK1D. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IF IHC IP WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to aa152-398 from human casein kinase I isoform delta protein.
