84-5779-56　CPNE1 50ul　559248

特徴

• Calcium-dependent phospholipid-binding protein that plays a role in calciummediated intracellular processes (PubMed:14674885).
• Involved in the TNFalpha receptor signaling pathway in a calcium-dependent manner(PubMed:14674885).
• Exhibits calcium-dependent phospholipid bindingproperties (PubMed:9430674, PubMed:19539605).
• Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385).
• May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145).
• May function in membrane trafficking (PubMed:9430674).
• Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740).
• Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (Paraffin): 1:20-1:200.
• Heat antigen retrieval is required using citrate buffer, pH 6.0
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.