84-5768-07　CLASP2 (HRP) 50ug　558679

特徴

• Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921).
• Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN).
• Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell.
• May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950).
• This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling.
• Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514).
• Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.