84-5726-39　BRD7 (HRP) 50ug　556616

特徴

• Acts both as coactivator and as corepressor.
• May play a role in chromatin remodeling.
• Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
• Induces dephosphorylation of GSK3B at 'Tyr-216'.
• Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity).
• Transcriptional corepressor that down-regulates the expression of target genes.
• Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac).
• Binds to the ESR1 promoter.
• Recruits BRCA1 and POU2F1 to the ESR1 promoter.
• Coactivator for TP53-mediated activation of transcription of a set of target genes.
• Required for TP53-mediated cell-cycle arrest in response to oncogene activation.
• Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters.
• Inhibits cell cycle progression from G1 to S phase.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.