Catalytic component of a P4-ATPase flippase complex which catalyzes thehydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.
Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules.
Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE).
Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes andneuronal axon membranes.
May be involved in vesicle trafficking in neuronal cells.
Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A.
Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human ATP8A2.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa358-570 from human phospholipid-transporting ATPase IB protein.
