84-5709-91　ATF5 100ul　555800

特徴

• Transcription factor that either stimulates or represses gene transcriptionthrough binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters.
• Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120,PubMed:21212266, PubMed:20654631).
• Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120).
• Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons.
• Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity).
• Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity).
• Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSNspecific genes (By similarity).
• May be involved in osteogenic differentiation(PubMed:22442021).
• Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1.
• Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614).
• Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity).
• Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083).
• In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486,PubMed:18701499).
• May act as a negative regulator of IL1B transductionpathway in liver (PubMed:24379400).
• Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613).
• Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764).
• Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner.
• Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.