84-5708-18　ASIC1 (FITC) 100ug　555714

特徴

• Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized.
• The channel generates a biphasic current with a fast inactivating and a slow sustained phase.
• Has high selectivity for sodium ions and can also transport lithium ions with high efficiency.
• Isoform 2 can also transport potassium, but with lower efficiency.
• It is nearly impermeable to the larger rubidium and cesium ions.
• Isoform 3 can also transport calcium ions.
• Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis.
• This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury.
• Heteromeric channel assembly seems to modulate channel properties.
• Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines.
• Modulates activity in the circuits underlying innate fear.
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.