Protein with hypoxia-induced expression in endothelial cells.
May act as a regulator of angiogenesis and modulate tumorigenesis.
Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.
May exert a protective function on endothelial cells through an endocrine action.
It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity.
In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM).
The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion.
It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human ANGPTL4.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa26-406 of human ANGPTL4. Subcellular Location: Secreted, Secreted, extracellular space, extracellular matrix
