Mediates dioxin toxicity and is involved in regulation of cell growth anddifferentiation.
Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT andsubsequently binding to the xenobiotic response element (XRE) sequencepresent in the promoter regulatory region of variety of genes.
RepressesCYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5.
Autoregulates its expression by associating with its own XRE site.
Applications:Suitable for use in ELISA and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human AHRR.
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa255-506 from human Aryl hydrocarbon receptor repressor protein.
