Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume and blood pressure.
AVP acts by binding to a set of specific seven-transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1) receptors regulate vasoconstriction, and are expressed in vascular smooth muscle, kidney, myometrium, bladder, adipocytes, hepatocytes, platelets and testis; V1b (V3) receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus; and V2 receptors of the kidney regulate the antidiuretic effects of AVP.
The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers.
V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol.
Specificity：Recognizes human Vasopressin receptor V2. Species Crossreactivity: human and mouse
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to rat Vasopressin receptor V2 at N-terminal.
