Arachidonic acid is converted by cyclooxygenase (COX) to prostaglandin H2 (PGH2), which is further converted to the derivative prostanoids PGD2, PGE2, PGF2 alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2).
Five classes of prostanoid receptors are recognized and named DP, EP, FP, IP and TP receptors corresponding to the agonist properties of the associated prostanoids.
FP receptors are found in smooth muscle where they mediate contraction, and are believed to be coupled via Gq/11 subunits to stimulate phosphatidyl inositol (PI) hydrolysis.
The FP agonist Fluprostenol (a PGF2 alpha analogue) is used in animal husbandry to synchronize oestrus and induce partruition.
FP receptors are known to mediate intraocular pressure, and FP agonists such as latanoprost and travoprost are drugs commonly use to treat glaucoma.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol.
Specificity：Recognizes rat PGF2 alpha receptor. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Mo Rt
Immunogen：Synthetic peptide corresponding to rat PGF2 at N-terminal. Species sequence homology: Wild boar and canine
