84-5671-68　［取扱停止］Peptide Tyrosine Tyrosine 100ul　378564

特徴

• Peptide tyrosine tyrosine (PYY) is a 36aa peptide, originally isolated from porcine gut, which exhibits striking sequence homology with members of the pancreatic polypeptide family, including neuropeptide tyrosine (NPY).
• The peptide is localised to enteroglucagon-containing (L/EG) and pancreatic (A) cells in many mammalian and nonmammalian species.
• PYY gene expression is upregulated by various growth factors, including growth hormone and insulin-like growth factor-1  and the physiological effects of PYY are mediated by G-protein (G alphai2) coupled Y-type receptors (‘Y2 receptors of a PYY-preferring subtype’).
• Various actions have been reported for PYY, including the inhibition of upper intestinal and exocrine pancreatic secretion, small intestinal water flux and as the mediator for the fat-induced ileal brake.
• The infusion of normal post-prandial concentrations of PYY[3-36] into human volunteers has been shown to significantly decrease appetite and reduce food intake, possibly via Y2R in the arcuate nucleus.
• This work stimulated a great deal of research activity showing that the truncated form of PYY reduced food intake in normal and obese humans and in rodents.
• Recently, the actions of PYY[3-36] and GLP-1[7-36] have been shown to inhibit food intake additively in humans and rats.
• Immunohistochemical studies on mice have shown that PYY is the earliest detectable peptide in both pancreatic islets and colonic endocrine cells, which suggest that PYY may be a useful marker for endocrine progenitor cells.
• Applications:Suitable for use in Western Blot and immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Westen Blot: 1:1000, ECLOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.