84-5671-41　［取扱停止］HSP90 Beta (PE) 50ug　378424

特徴

• The 90kD molecular chaperone family includes 90kD heat shock protein Hsp90 and 94kD glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum.
• Mammalian cells express inducible Hsp90 alpha and constitutive Hsp90 beta isoforms that are encoded by separate genes.
• The aa sequences of human and yeast Hsp90 alpha are 85% and 90% homologous to those of Hsp90 beta, respectively.
• All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity.
• These ubiquitous and highly conserved proteins account for 1-2% of all cellular protein in most cells.
• Hsp90 functions as part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions.
• In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control by serving as a chaperone for many key signaling molecules including steroid receptors, cell cycle kinases involved in signal transduction, and p53.
• As many of these client proteins are known oncogenes, Hsp90 inhibitors such as 17-AAG, a geldanamycin analog, have been of benefit in the treatment of many cancers.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 10ug/mlOptimal dilutions to be determined by the researcher.
• Storage and StabilityMay be stored at 4°C before opening.
• DO NOT FREEZE! Stable at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Stable for 12 months at 4°C.
• Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
• PE conjugates are sensitive to light.