The cannabinoid receptors CB1 (expressed primarily throughout the central nervous system) and CB2 (expressed in peripheral tissues) are members of the seven-transmembrane domain-containing family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta-9-tetrahydrocannabinol (delta-9-THC).
Significant evidence suggests that additional cannabinoid receptors may contribute to the many behavioral, vascular, and immunological effects of agonists such as THC and endogenous cannabinoids.
Evidence suggests GPR55 may act as a cannabinoid receptor, although its definition as a bona fide "CB3" receptor remains controversial.
GPR55 is highly expressed in large-diameter dorsal root ganglion (DRG) neurons, and its activation by cannabinoid compounds (THC, JWH015, and anandamide) has been shown to release calcium from IP3-sensitive ER stores.
These findings are opposed by evidence that suggests GPR55 is an intrinsic receptor for lysophosphatidylinositol (LPI).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol.
Specificity：Recognizes rat GPR55. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo Rt
Immunogen：Synthetic peptide corresponding to rat GPR5 at C-terminal.
