84-5670-91　［受注停止］COP9 Signalosome Csn6 100ul　378250

特徴

• The COP9 signalosome, once defined as a repressor complex of light activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms.
• The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor.
• A multifaceted role of the COP9 signalosome in cell-signalling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signalling pathways and cell-cycle progression.
• The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological rüle in animals has yet to be determined.
• The COP9 signalosome, also known as the the COP9 complex and JAB1-containing signalosome, is a conserved nuclear protein complex found in plants and animals.
• It is composed of eight distinct subunits, designated S1 to S8 (very recently re-designated Csn1-Csn8) according to the molecular weight of the mammalian complex subunits.
• Subunit composition and the subunit sequences are substantially conserved between the mammalian and the plant complexes, implying that the complex has a conserved cellular function in higher eukaryotic organisms.
• The role and function of Csn6 has yet to be determined although this subunit is known to interact with subunits Csn2 and Csn7 within the COP9 signalosome.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000 against both endogenous and purified signalosome preparations.
• Detects a band of ~33.5kDOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.