Alpha-Synuclein accumulates in Lewy bodies, which are intraneuronal cytoplasmic inclusions present in the brains of sporadic Parkinson's disease patients, and is implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders.
alpha-Synuclein appears to associate with other proteins that aggregate and is found in beta-amyloid plaques and neuritic tangles in Alzheimer's disease.
Applications:Suitable for use in Western Blot and immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000-1:20,000Optimal dilution determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified by caprylic acid and ammonium sulphate precipitation.
Form：Supplied as a liquid in PBS, pH 7.4, 10mM sodium azide.
Specificity：Recognizes human brain-derived alpha-synuclein. The antibody also reacts with rat brain-derived alpha-synuclein but reactivity appears substantially less than with human. Does not cross-react with mouse alpha-synuclein.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to [Cys] + aa117-131 of human alpha-synuclein conjugated to KLH. The sequence is conserved in rat alpha-synuclein except for two substitutions, namely Asp121Ser and Asn122Ser.
