YTHDF2 encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain.
The YTH domain is typical for the eukaryotes and is particularly abundant in plants.
The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA.
In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction.
An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity.
In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia.
This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.
Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human YTHD2.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human YTHD2.
