USP11 (ubiquitin specific peptidase 11) is a protein coding gene.
Among its related pathways are transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding.
GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity.
An important paralog of this gene is USP4.
rotease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed: 12084015, PubMed: 15314155, PubMed: 17897950, PubMed: 19874889, PubMed: 20233726, PubMed: 24724799).
Inhibits the degradation of target proteins by the proteasome (PubMed: 12084015).
Cleaves preferentially Lys-6 and Lys-63-linked ubiquitin chains.
Has lower activity with Lys-11 and Lys-33-linked ubiquitin chains, and extremely low activity with Lys-27, Lys-29 and Lys-48-linked ubiquitin chains (in vitro) (PubMed: 24724799).
Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed: 17897950, PubMed: 19874889).
Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed: 15314155, PubMed: 20233726).
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human USP11. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to the Internal region of human USP11.
