UFD1 (ubiquitin recognition factor In ER associated degradation 1) is a protein coding gene.
Diseases associated with UFD1 include melocardiofacial syndrome and inclusion body myopathy with Paget disease of bone and frontotemporal dementia.
Among its related pathways are protein processing in endoplasmic reticulum and translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.
The protein encoded by UFD1 forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins.
In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis.
Mutations in UFD1 have been associated with catch 22 syndrome as well as cardiac and craniofacial defects.
Alternative splicing results in multiple transcript variants encoding different isoforms.
A related pseudogene has been identified on chromosome 18.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human UFD1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human UFD1.
