TRPM7 (transient receptor potential cation channel subfamily M member 7) is a protein coding gene.
Among its related pathways are TRP channels and cellular senescence (KEGG).
TRPM7 belongs to the melastatin subfamily of transient receptor potential family of ion channels.
The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase.
The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis.
The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis.
Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
TRPM7 may also be associated with defects of cardiac function.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human TRPM7. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human TRPM7.
