TRIM56 (tripartite motif containing 56) is a protein coding gene.
Among its related pathways are cytosolic sensors of pathogen-associated DNA and innate immune system.
GO annotations related to this gene include poly(A) RNA binding and ubiquitin-protein transferase activity.
An important paralog of this gene is TRIM3.
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed: 21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to Lys-63-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling.
Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES.
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed: 22948160).
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human TRI56. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa121-170 from human TRI56.
